Spyre Therapeutics, Inc.
SYRE
Rank in Stocks
#2471
Spyre Therapeutics, Inc. is a biotechnology firm operating at the preclinical... Spyre Therapeutics, Inc. is a biotechnology firm operating at the preclinical stage, dedicated to creating innovative treatments for individuals afflicted with inflammatory bowel disease (IBD). Among its pipeline candidates is SPY001, a human monoclonal immunoglobulin G1 antibody specifically engineered to target and bind with the a4ß7 integrin. This particular therapy is under development for addressing both ulcerative colitis and Crohn's disease, two forms of IBD. Furthermore, Spyre Therapeutics is advancing SPY002, another human monoclonal antibody that aims to interact with tumor necrosis factor-like ligand 1A (TL1A). A synergistic approach is also being explored with SPY120, a compound that merges the anti-a4ß7 action of SPY001 with the anti-TL1A activity of SPY002. All these programs are currently undergoing preclinical evaluation. Beyond these, the company's early-stage portfolio encompasses several additional promising candidates: SPY003, an anti-IL-23 monoclonal antibody; SPY004, a monoclonal antibody with a novel mechanism of action; SPY130, which combines anti-a4ß7 and anti-IL-23 antibodies; and SPY230, a dual antibody therapy featuring anti-TL1A and anti-IL-23 components. Originally incorporated in 2013, the organization was previously known as Aeglea BioTherapeutics, Inc., before rebranding to Spyre Therapeutics, Inc. in November 2023. Its headquarters are located in Waltham, Massachusetts.
Share Price
$85.55
Last synced: 2026-10-19
Market Cap
$7.90B
Change (1 day)
7.07%
Change (1 year)
264.18%
Country
US
Trade Spyre Therapeutics, Inc. (SYRE)
Category
Healthcare
Earnings for Spyre Therapeutics, Inc. (SYRE)
Earnings in Jun 2026 TTM: $-178.92M
According to Spyre Therapeutics, Inc. latest financial reports the company's current earnings are $-178.92M. In 2023 the company made an earning of $-338.82M, a decrease compared to its 2022 earnings that were of $-83.95M. The earnings displayed on this page are the earnings before interest and taxes or simply EBIT.
Earnings history for Spyre Therapeutics, Inc. from 2014 to 2026
Earnings at the end of each year
| Year | Earnings | Change |
|---|---|---|
| 2026 (TTM) | $-178.92M | -13.97% |
| 2024 | $-207.97M | -38.62% |
| 2023 | $-338.82M | 303.59% |
| 2022 | $-83.95M | 27.86% |
| 2021 | $-65.66M | -18.83% |
| 2020 | $-80.89M | 3.37% |
| 2019 | $-78.25M | 76.45% |
| 2018 | $-44.35M | 62.83% |
| 2017 | $-27.24M | 25.52% |
| 2016 | $-21.70M | 92.10% |
| 2015 | $-11.30M | 9.16% |
| 2014 | $-10.35M | 0.00% |
Earnings for similar companies or competitors
| Company | Earnings | Earnings Difference | Country |
|---|---|---|---|
| $5.27B | -3,048.22% |
US
|
|
| $-3.09B | 1,625.37% |
US
|
|
| $-4.02B | 2,144.71% |
AU
|
|
| - | - |
CH
|
|
| $1.95B | -1,190.25% |
NL
|
