Spyre Therapeutics, Inc.
SYRE
Rank in Stocks
#2595
Spyre Therapeutics, Inc. is a biotechnology firm operating at the preclinical... Spyre Therapeutics, Inc. is a biotechnology firm operating at the preclinical stage, dedicated to creating innovative treatments for individuals afflicted with inflammatory bowel disease (IBD). Among its pipeline candidates is SPY001, a human monoclonal immunoglobulin G1 antibody specifically engineered to target and bind with the a4ß7 integrin. This particular therapy is under development for addressing both ulcerative colitis and Crohn's disease, two forms of IBD. Furthermore, Spyre Therapeutics is advancing SPY002, another human monoclonal antibody that aims to interact with tumor necrosis factor-like ligand 1A (TL1A). A synergistic approach is also being explored with SPY120, a compound that merges the anti-a4ß7 action of SPY001 with the anti-TL1A activity of SPY002. All these programs are currently undergoing preclinical evaluation. Beyond these, the company's early-stage portfolio encompasses several additional promising candidates: SPY003, an anti-IL-23 monoclonal antibody; SPY004, a monoclonal antibody with a novel mechanism of action; SPY130, which combines anti-a4ß7 and anti-IL-23 antibodies; and SPY230, a dual antibody therapy featuring anti-TL1A and anti-IL-23 components. Originally incorporated in 2013, the organization was previously known as Aeglea BioTherapeutics, Inc., before rebranding to Spyre Therapeutics, Inc. in November 2023. Its headquarters are located in Waltham, Massachusetts.
Share Price
$80.03
Last synced: 2026-10-16
Market Cap
$7.39B
Change (1 day)
-0.09%
Change (1 year)
256.14%
Country
US
Trade Spyre Therapeutics, Inc. (SYRE)
Category
Healthcare
Operating Margin for Spyre Therapeutics, Inc. (SYRE)
Operating Margin as of October 2026 TTM: -222.49%
According to Spyre Therapeutics, Inc. latest financial reports and stock price the company's current Operating Margin (TTM) is -222.49%. At the end of 2023 the company had an Operating Margin of -27,347.97%.
Operating Margin history for Spyre Therapeutics, Inc. from 2013 to 2026
Operating Margin at the end of each year
| Year | Operating Margin | Change |
|---|---|---|
| 2026 (TTM) | -222.49% | -100.00% |
| 2024 | 0.00% | -100.00% |
| 2023 | -27,347.97% | 651.27% |
| 2022 | -3,640.23% | 939.09% |
| 2021 | -350.33% | 0.00% |
| 2020 | 0.00% | 0.00% |
| 2019 | 0.00% | -100.00% |
| 2018 | -1,169.32% | 119.91% |
| 2017 | -531.72% | 12.33% |
| 2016 | -473.34% | 154.55% |
| 2015 | -185.95% | 0.00% |
| 2014 | 0.00% | 0.00% |
| 2013 | 0.00% | 0.00% |
Operating Margin for similar companies or competitors
| Company | Operating Margin | Operating Margin Difference | Country |
|---|---|---|---|
| 38.59% | -100.17% |
US
|
|
| -149.01% | -99.33% |
US
|
|
| 25.57% | -100.11% |
AU
|
|
| 0.00% | - |
CH
|
|
| 28.81% | -100.13% |
NL
|
What is a company's Operating Margin?
The operating margin is a key indicator to assess the profitability of a company. Higher operating margins are generaly better as they show that a company is able to sell its products or services for much more than their production costs. The operating margin is calculated by dividing a company's earnings by its revenue.