Spyre Therapeutics, Inc.
SYRE
Rank in Stocks
#2333
Spyre Therapeutics, Inc. is a biotechnology firm operating at the preclinical... Spyre Therapeutics, Inc. is a biotechnology firm operating at the preclinical stage, dedicated to creating innovative treatments for individuals afflicted with inflammatory bowel disease (IBD). Among its pipeline candidates is SPY001, a human monoclonal immunoglobulin G1 antibody specifically engineered to target and bind with the a4ß7 integrin. This particular therapy is under development for addressing both ulcerative colitis and Crohn's disease, two forms of IBD. Furthermore, Spyre Therapeutics is advancing SPY002, another human monoclonal antibody that aims to interact with tumor necrosis factor-like ligand 1A (TL1A). A synergistic approach is also being explored with SPY120, a compound that merges the anti-a4ß7 action of SPY001 with the anti-TL1A activity of SPY002. All these programs are currently undergoing preclinical evaluation. Beyond these, the company's early-stage portfolio encompasses several additional promising candidates: SPY003, an anti-IL-23 monoclonal antibody; SPY004, a monoclonal antibody with a novel mechanism of action; SPY130, which combines anti-a4ß7 and anti-IL-23 antibodies; and SPY230, a dual antibody therapy featuring anti-TL1A and anti-IL-23 components. Originally incorporated in 2013, the organization was previously known as Aeglea BioTherapeutics, Inc., before rebranding to Spyre Therapeutics, Inc. in November 2023. Its headquarters are located in Waltham, Massachusetts.
Share Price
$91.87
Market Cap
$8.48B
Change (1 day)
8.44%
Change (1 year)
291.10%
Country
US
Trade Spyre Therapeutics, Inc. (SYRE)
Category
Healthcare
P/E ratio for Spyre Therapeutics, Inc. (SYRE)
P/E ratio as of October 2026 TTM: -40.32
According to Spyre Therapeutics, Inc. latest financial reports and stock price the company's current price-to-earnings ratio (TTM) is -40.32. At the end of 2023 the company had a P/E ratio of -0.44.
P/E ratio history for Spyre Therapeutics, Inc. from 2013 to 2026
P/E ratio at the end of each year
| Year | P/E Ratio | Change |
|---|---|---|
| 2026 (TTM) | -40.32 | 666.60% |
| 2024 | -5.26 | 1,101.32% |
| 2023 | -0.44 | -3.18% |
| 2022 | -0.45 | -90.47% |
| 2021 | -4.75 | -8.60% |
| 2020 | -5.19 | 66.46% |
| 2019 | -3.12 | -11.30% |
| 2018 | -3.52 | 17.03% |
| 2017 | -3.01 | 53.08% |
| 2016 | -1.96 | -80.14% |
| 2015 | -9.89 | -23.46% |
| 2014 | -12.92 | 0.00% |
| 2013 | 0.00 | 0.00% |
P/E ratio for similar companies or competitors
| Company | P/E Ratio | P/E Ratio Difference | Country |
|---|---|---|---|
| 28.78 | -171.38% |
US
|
|
| -28.36 | -29.67% |
US
|
|
| -24.57 | -39.07% |
AU
|
|
| - | - |
CH
|
|
| 30.33 | -175.22% |
NL
|
How to read a P/E ratio?
The Price/Earnings ratio measures the relationship between a company's stock price and its earnings per share.
A low but positive P/E ratio stands for a company that is generating high earnings compared to its current valuation and might be undervalued. A company with a high negative (near 0) P/E ratio stands for a company that is generating heavy losses compared to its current valuation.
Companies with a P/E ratio over 30 or a negative one are generaly seen as "growth stocks" meaning that investors typically expect the company to grow or to become profitable in the future.
Companies with a positive P/E ratio bellow 10 are generally seen as "value stocks" meaning that the company is already very profitable and unlikely to strong growth in the future.