Ionis Pharmaceuticals, Inc.
IONS
Rank in Stocks
#2670
Founded in 1989 and headquartered in Carlsbad, California, Ionis... Founded in 1989 and headquartered in Carlsbad, California, Ionis Pharmaceuticals, Inc. is a biopharmaceutical company specializing in the discovery and development of RNA-targeted therapies within the United States. Its commercial portfolio includes three key medications: SPINRAZA, prescribed for spinal muscular atrophy (SMA) in both children and adults; TEGSEDI, an injectable treatment targeting polyneuropathy associated with hereditary transthyretin-mediated amyloidosis in adult patients; and WAYLIVRA, which addresses familial chylomicronemia syndrome and familial partial lipodystrophy. Ionis also maintains a robust pipeline, with several drug candidates currently in Phase 3 clinical trials. These include Eplontersen, a monthly self-administered subcutaneous injection designed for all forms of TTR amyloidosis; Olezarsen, intended for individuals with severe hypertriglyceridemia (SHTG); Donidalorsen, for patients suffering from hereditary angioedema; ION363, aimed at amyotrophic lateral sclerosis (ALS); Pelacarsen, developed for those with established cardiovascular disease and elevated lipoprotein(a); and Tofersen, which works by inhibiting the production of superoxide dismutase 1. Beyond these late-stage assets, the company is actively researching treatments for metabolic, infectious, renal, and ophthalmic diseases, as well as various types of cancer. The firm engages in significant collaborations, notably a strategic partnership with Biogen Inc. Additionally, it holds licensing and collaboration agreements with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc.
Share Price
$42.95
Last synced: 2026-10-16
Market Cap
$7.14B
Change (1 day)
-2.65%
Change (1 year)
-41.23%
Country
US
Trade Ionis Pharmaceuticals, Inc. (IONS)
Category
Healthcare
Operating Margin for Ionis Pharmaceuticals, Inc. (IONS)
Operating Margin as of October 2026 TTM: -68.09%
According to Ionis Pharmaceuticals, Inc. latest financial reports and stock price the company's current Operating Margin (TTM) is -68.09%. At the end of 2023 the company had an Operating Margin of -44.91%.
Operating Margin history for Ionis Pharmaceuticals, Inc. from 2000 to 2026
Operating Margin at the end of each year
| Year | Operating Margin | Change |
|---|---|---|
| 2026 (TTM) | -68.09% | 1.07% |
| 2024 | -67.37% | 50.01% |
| 2023 | -44.91% | -35.86% |
| 2022 | -70.02% | 1,777.21% |
| 2021 | -3.73% | -84.19% |
| 2020 | -23.59% | -172.38% |
| 2019 | 32.59% | -418.57% |
| 2018 | -10.23% | -311.80% |
| 2017 | 4.83% | -136.15% |
| 2016 | -13.36% | -49.96% |
| 2015 | -26.70% | 19.78% |
| 2014 | -22.29% | -36.46% |
| 2013 | -35.08% | -48.06% |
| 2012 | -67.54% | -5.88% |
| 2011 | -71.76% | 60.97% |
| 2010 | -44.58% | 96.82% |
| 2009 | -22.65% | 85.96% |
| 2008 | -12.18% | -78.23% |
| 2007 | -55.94% | -79.85% |
| 2006 | -277.67% | 94.88% |
| 2005 | -142.48% | -48.47% |
| 2004 | -276.49% | 75.00% |
| 2003 | -157.99% | 149.31% |
| 2002 | -63.37% | -26.77% |
| 2001 | -86.54% | 11.21% |
| 2000 | -77.82% | 0.00% |
Operating Margin for similar companies or competitors
| Company | Operating Margin | Operating Margin Difference | Country |
|---|---|---|---|
| 38.59% | -100.57% |
US
|
|
| -149.01% | -97.81% |
US
|
|
| 25.57% | -100.38% |
AU
|
|
| 0.00% | - |
CH
|
|
| 28.81% | -100.42% |
NL
|
What is a company's Operating Margin?
The operating margin is a key indicator to assess the profitability of a company. Higher operating margins are generaly better as they show that a company is able to sell its products or services for much more than their production costs. The operating margin is calculated by dividing a company's earnings by its revenue.