Upstream Bio, Inc.
UPB
Rank in Stocks
#16742
Upstream Bio, Inc. is a biotechnology company in the clinical development... Upstream Bio, Inc. is a biotechnology company in the clinical development stage, dedicated to innovating therapies for inflammatory conditions, particularly those affecting the severe respiratory system. Its pipeline notably features verekitug, a monoclonal antibody designed to selectively target and suppress the thymic stromal lymphopoietin receptor. Beyond this, the company is actively developing treatments for severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Established in 2021, Upstream Bio maintains its operational base in Waltham, Massachusetts.
Share Price
$3.58
Last synced: 2026-11-09
Market Cap
$196.08M
Change (1 day)
10.84%
Change (1 year)
-84.91%
Country
Stock data: Financial Modeling PrepΒ·Updated Β·Not investment adviceΒ·How we calculate this
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Category
Healthcare
Operating Margin for Upstream Bio, Inc. (UPB)
Operating Margin as of November 2026 TTM: -5,382.65%
According to Upstream Bio, Inc.'s latest financial reports, its current operating margin (TTM) is -5,382.65%. At the end of 2025 the company had an operating margin of -5,618.82%.
Operating Margin history for Upstream Bio, Inc. from 2022 to 2026
Operating Margin at the end of each year
| Year | Operating Margin | Change |
|---|---|---|
| 2026 (TTM) | -5,382.65% | -4.20% |
| 2025 | -5,618.82% | 71.24% |
| 2024 | -3,281.18% | 94.68% |
| 2023 | -1,685.46% | -14.56% |
| 2022 | -1,972.69% | 0.00% |
Operating Margin for similar companies or competitors
| Company | Operating Margin | Operating Margin Difference | Country |
|---|---|---|---|
| 38.59% | -100.01% |
US
|
|
| -149.01% | -99.97% |
US
|
|
| 25.57% | -100.00% |
AU
|
|
| 31.23% | -100.01% |
BE
|
|
| 29.35% | -100.01% |
NL
|
What is a company's Operating Margin?
The operating margin is a key indicator to assess the profitability of a company. Higher operating margins are generaly better as they show that a company is able to sell its products or services for much more than their production costs. The operating margin is calculated by dividing a company's earnings by its revenue.
Questions about Upstream Bio, Inc.'s operating margin
What is Upstream Bio, Inc.'s operating margin?
Upstream Bio, Inc.'s operating margin is -5,382.65%, as of Nov 2026.
What was Upstream Bio, Inc.'s operating margin in 2025?
In 2025, Upstream Bio, Inc.'s operating margin was -5,618.82%, compared with -3,281.18% in 2024.
How has Upstream Bio, Inc.'s operating margin changed since 2022?
From 2022 to 2025, Upstream Bio, Inc.'s operating margin was highest in 2023 (-1,685.46%) and lowest in 2025 (-5,618.82%).
How does Upstream Bio, Inc.'s operating margin compare with similar companies?
Upstream Bio, Inc.'s operating margin (-5,382.65%) is lower than that of all 5 similar companies listed above. The highest among them is Vertex Pharmaceuticals Incorporated, with 38.59%.